NIR afterglow nanosystem for photodynamic therapy.
Bingxin ShuShubi ZhaoYuling ZhangQinchao SunZhen HuangPublished in: RSC advances (2024)
Within the milieu of immune dysfunction, reactive oxygen species (ROS) play a pivotal role in inducing immunogenic cell death (ICD), countering the dysregulated tumor microenvironment. However, the administration of ROS at indiscriminate dosages may provoke deleterious immune responses. Therefore, precise regulation of ROS production is crucial to achieve efficacious therapeutic outcomes. We engineered an innovative afterglow nanosystem which is capable of real-time monitoring of ROS levels. Our findings reveal that Ru/CYQ@CPPO exhibits a markedly enhanced and prolonged afterglow luminescence, coupled with superior singlet oxygen (O 2 ) generation, compared to the commercially available indocyanine green (ICG). In vitro studies demonstrated that Ru/CYQ@CPPO exhibits remarkable efficacy in photodynamic therapy (PDT) under irradiation at a wavelength of 450 nm. Furthermore, a significant correlation ( R 2 = 0.987) was observed between the intensity of afterglow luminescence and the rate of cancer cell inhibition.
Keyphrases
- photodynamic therapy
- reactive oxygen species
- cell death
- fluorescence imaging
- energy transfer
- dna damage
- immune response
- cell cycle arrest
- quantum dots
- oxidative stress
- single cell
- metabolic syndrome
- gene expression
- drug delivery
- cell proliferation
- skeletal muscle
- toll like receptor
- radiation therapy
- insulin resistance
- glycemic control