Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals.
Agnieszka MechlińskaMariusz S WigluszJakub SłupskiAdam WlodarczykWiesław Jerzy CubałaPublished in: Brain sciences (2023)
Major depressive disorder and bipolar disorder are the leading causes of global disability. Approximately 50% of patients fail to attain remission, prompting a pronounced focus on the significance of dietary patterns and specific nutrients within the pathophysiology of mood disorders. The connection between chronic diseases and mood disorders follows a bidirectional pattern: physical ailments are interrelated with affective disorders, and, concurrently, mood symptoms often precede chronic diseases and have the potential to worsen their prognosis. Nutraceuticals affect factors that could potentially impact the onset of mood disorders: monoamines and brain-derived neurotrophic factor (BDNF) concentrations, neuroinflammation, oxidative stress, and sleep quality. Furthermore, mood disorders rarely manifest in isolation. Typically, such patients concurrently experience other mental disorders or somatic comorbidities: obesity, hypertension, diabetes, polycystic ovary syndrome (PCOS), etc., where providing nutritional support is also pertinent. To optimize the therapeutic approach for individuals with mood disorders, incorporating nutritional support may not solely ameliorate symptoms stemming directly from the mental condition, but also indirectly through interventions targeting comorbidities.
Keyphrases
- bipolar disorder
- major depressive disorder
- sleep quality
- polycystic ovary syndrome
- end stage renal disease
- depressive symptoms
- physical activity
- oxidative stress
- type diabetes
- newly diagnosed
- insulin resistance
- ejection fraction
- blood pressure
- mental health
- public health
- traumatic brain injury
- healthcare
- metabolic syndrome
- chronic kidney disease
- multiple sclerosis
- dna damage
- gene expression
- risk assessment
- human health
- rheumatoid arthritis
- climate change
- body mass index
- adipose tissue
- inflammatory response
- ischemia reperfusion injury
- health information
- lps induced