Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
Osama Shiraz ShahAzadeh NasrazadaniJulia FoldiJennifer M AtkinsonCelina G KleerPriscilla F McAuliffeTyler J JohnstonWayne StallaertEdaise M da SilvaPier SelenicaHiginio DopesoFresia ParejaDiana MandelkerBritta WeigeltJorge S Reis-FilhoRohit BhargavaPeter C LucasAdrian V LeeSteffi OesterreichPublished in: bioRxiv : the preprint server for biology (2024)
MDLC displays both ductal and lobular tumor regions. Our multi-omic profiling approach revealed that these morphologically distinct tumor regions harbor distinct intrinsic subtypes and oncogenic features that may cause prognostic uncertainty and therapeutic dilemma. Thus histopathological/molecular profiling of individual tumor regions may guide clinical decision making and benefit patients with MDLC, particularly in the advanced setting where there is increased reliance on next generation sequencing.