Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.

Ayano YoshidoGota SudoAkira TakasawaHironori Aoki Hiroshi KitajimaEiichiro YamamotoTakeshi NiinumaTaku HaradaToshiyuki KuboHajime SasakiKazuya IshiguroAkira YorozuMasahiro KaiAkio KatanumaHiro-O YamanoMakoto OsanaiHiroshi NakaseHiromu Suzuki

Published in: Journal of gastroenterology and hepatology (2022)

Our results suggest that interplay between macrophages and CRC cells leads to recruitment of neutrophils to the invasive front of T1 CRCs and that SAA1 secreted by CRC cells activate neutrophils to promote invasion.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death