Naringenin Alleviates Radiation-Induced Intestinal Injury by Inhibiting TRPV6 in Mice.

Zhi LingZheng WangLin ChenJingxian MaoDongmei MaXiao HanLinlin TianQingtian ZhuGuotao LuXuebing YanYanbing DingWeiming XiaoYong ChenAijun PengXudong Yin

Published in: Molecular nutrition & food research (2024)

NAR inhibits the apoptosis pathway by downregulating TRPV6 and reducing calcium ion level, thereby alleviating RIII. Therefore, NAR is a promising therapeutic drug for RIII.

Keyphrases

radiation induced
radiation therapy
neuropathic pain
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
high fat diet induced
cell death
spinal cord
mouse model
metabolic syndrome
drug induced
adverse drug
wild type
cell proliferation