Monocyte-Macrophage Lineage Cell Fusion.
Małgorzata KlocArijita SubuddhiAhmed UosefJacek Z KubiakRafik M GhobrialPublished in: International journal of molecular sciences (2022)
Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte-macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte-macrophage lineage cell fusion and the role of actin-based structures in cell fusion.
Keyphrases
- single cell
- induced apoptosis
- dendritic cells
- cell therapy
- cell cycle arrest
- oxidative stress
- endothelial cells
- peripheral blood
- squamous cell carcinoma
- stem cells
- cell death
- immune response
- endoplasmic reticulum stress
- signaling pathway
- mass spectrometry
- cell proliferation
- bone marrow
- papillary thyroid
- diabetic rats
- pi k akt
- young adults