Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data.

Anish N KapadiaKrish BillimoriaPrarthna Desai James T Grist Chinthaka C Heyn Pejman Jabehdar Maralani Sean Symons Fulvio Zaccagna

Published in: Journal of clinical neurology (Seoul, Korea) (2023)

The results of this study suggest that a reduction in CBF at the entorhinal cortex precedes tau deposition. Further work is needed to understand the mechanism underlying tau deposition in aging and disease.

Keyphrases

cerebrospinal fluid
functional connectivity
electronic health record
cognitive impairment
big data
machine learning
deep learning