Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles.

Bram Van den BroekCharlotte WuytsAngela Sisto Isabel Pintelon Jean-Pierre Timmermans Veerle Somers Vincent Timmerman Niels Hellings Joy Irobi

Published in: Cell communication and signaling : CCS (2022)

We demonstrate that the functions of oligodendroglia secreted EVs enriched with HSPB8 have a supportive role, comparable to the native OL-EVs. Further development of engineered oligodendroglia derived EVs could be a novel therapeutic strategy in countering chronic inflammation. Video Abstract.

Keyphrases

oxidative stress
heat shock
heat shock protein
dna damage
diabetic rats
ischemia reperfusion injury
cell death
induced apoptosis
endoplasmic reticulum stress
signaling pathway
mass spectrometry