Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
Huihui ZengTiao LiXue HeShan CaiHong LuoPing ChenYan ChenPublished in: Respiratory research (2020)
Cigarette-induced oxidative stress mediates pulmonary apoptosis and hypermethylation of the Bcl-2 promoter in emphysema models through DNMT1.
Keyphrases
- dna methylation
- oxidative stress
- diabetic rats
- gene expression
- chronic obstructive pulmonary disease
- endoplasmic reticulum stress
- cell cycle arrest
- lung function
- induced apoptosis
- ischemia reperfusion injury
- dna damage
- cell death
- pulmonary fibrosis
- high glucose
- pulmonary hypertension
- idiopathic pulmonary fibrosis
- transcription factor
- hydrogen peroxide
- nitric oxide
- smoking cessation
- heat shock