Decumbic anhydride from the stem barks of Swintonia floribunda (Anacardiaceae).

Phu Hoang DangTho Huu LeTruong Nhat Van DoHai Xuan NguyenMai Thanh Thi NguyenNhan Trung Nguyen

Published in: Zeitschrift fur Naturforschung. C, Journal of biosciences (2020)

From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), decumbic anhydride (1) and four known compounds 2-5 were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of 13C NMR chemical shifts was carried out to clarify the structure of 1. The absolute configuration of 1 was assigned based on the Cotton effects in its ECD spectrum. Compound 1 showed potent tyrosinase inhibitory activity with an IC50 value of 52.2 μM.

Keyphrases

molecular docking
high resolution
magnetic resonance
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density functional theory
big data
solid state
mass spectrometry
crystal structure
molecular dynamics simulations
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