Obesity in children with acute promyelocytic leukemia: What is its prevalence and prognostic significance?

Kathryn L LauriePaul LeeAlfred RademakerTodd A AlonzoYi-Cheng WangBayard L PowellDiana WuRichard LarsonMatthew A KutnyJohn GregoryNobuko HijiyaJames Feusner

Published in: Pediatric blood & cancer (2022)

The prevalence of obesity is higher in pediatric patients with APL compared to the general population. The decreased EFS and OS in obese patients on AAML0631 suggest that the presence of obesity can influence outcomes using the most current treatment. These findings support the need for further research on the potential role of obesity in pediatric APL leukemogenesis.

Keyphrases

insulin resistance
weight loss
metabolic syndrome
obese patients
high fat diet induced
type diabetes
bariatric surgery
weight gain
risk factors
gastric bypass
bone marrow
acute myeloid leukemia
adipose tissue
skeletal muscle
risk assessment
climate change
glycemic control
young adults
replacement therapy