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Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.

Kristen R HollingerMatthew D SmithLeslie A KirbyEva PrchalovaJesse AltRana RaisPeter A CalabresiBarbara S Slusher
Published in: Neurology(R) neuroimmunology & neuroinflammation (2019)
JHU-083, a well-tolerated, brain penetrable glutamine antagonist, is a promising novel treatment for both the physical and cognitive deficits of MS.
Keyphrases
  • mass spectrometry
  • multiple sclerosis
  • physical activity
  • ms ms
  • mental health
  • white matter
  • resting state
  • combination therapy
  • functional connectivity
  • cerebral ischemia