Enhanced in Vivo Blood Brain Barrier Transcytosis of Macromolecular Cargo Using an Engineered pH-sensitive Mouse Transferrin Receptor Binding Nanobody.
Thomas J EsparzaShiran SuCaroline M FrancescuttiElvira RodionovaJoong Hee KimDavid L BrodyPublished in: bioRxiv : the preprint server for biology (2023)
may be a useful tool for rapid and efficient modular transport of diagnostic and therapeutic macromolecular cargos across the blood brain barrier in mouse models. Additional development will be required to determine whether this nanobody-based shuttle system will be useful for imaging and fast-acting therapeutic applications.