Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer.
Kathryn M PflugRaquel SitcheranPublished in: International journal of molecular sciences (2020)
NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of the noncanonical NF-κB pathway, has important roles in regulating immunity and inflammation. In addition, NIK is vital for maintaining cellular health through its control of fundamental cellular processes, including differentiation, growth, and cell survival. As such aberrant expression or regulation of NIK is associated with several disease states. For example, loss of NIK leads to severe immune defects, while the overexpression of NIK is observed in inflammatory diseases, metabolic disorders, and the development and progression of cancer. This review discusses recent studies investigating the therapeutic potential of NIK inhibitors in various diseases.
Keyphrases
- oxidative stress
- signaling pathway
- papillary thyroid
- lps induced
- healthcare
- pi k akt
- protein kinase
- public health
- squamous cell
- tyrosine kinase
- cell proliferation
- mental health
- immune response
- transcription factor
- squamous cell carcinoma
- drug delivery
- health information
- risk assessment
- climate change
- toll like receptor
- young adults