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Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain.

Qiwen DongStephen HarperEmma McSpaddenSophie S SonMarie-Maude AllenHuaiying LinRita C SmithCarolyn MetcalfeVictoria BurgoChe WoodsonAnitha SundararajanAmber RoseMary McMillinDavid MoranJessica LittleMichael MullowneyAshley M SidebottomAimee ShenLouis-Charles FortierEric G Pamer
Published in: bioRxiv : the preprint server for biology (2024)
strains in mice when co-infected at a 1:1 ratio. Our data suggest that inter-strain competition results from ST1-75's more rapid depletion of amino acids than the virulent R20291 strain. Our study identifies inter-strain nutrient depletion as a potentially exploitable mechanism to reduce the incidence of CDI.
Keyphrases
  • clostridium difficile
  • amino acid
  • escherichia coli
  • risk factors
  • big data
  • type diabetes
  • gene expression
  • metabolic syndrome
  • high fat diet induced
  • adipose tissue
  • deep learning
  • data analysis
  • sensitive detection