Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy.

Ping Na ZhangJing Yi TangKe Zhen YangQi Yan ZhengZhao Cheng DongYun Ling GengYu Ning LiuWei Jing Liu

Published in: Drug design, development and therapy (2022)

Triptolide could exert antiproteinuric and renoprotective effects in PHN. The therapeutic mechanism of triptolide may be associated with the regulation of PI3K/AKT/mTOR signaling pathway. This study demonstrates the pharmacological mechanism of triptolide in the treatment of MN and provides scientific evidence for basic and clinical research.

Keyphrases

signaling pathway
epithelial mesenchymal transition
combination therapy
pi k akt
endoplasmic reticulum stress
ionic liquid
induced apoptosis
data analysis