IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.

Yuki NakamuraRiho AiharaHisataka IwataTakehito KuwayamaKoumei Shirasuna

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)

We suggest that senescence-associated IL1s cause SASP production in bovine OECs and CCL2 induced by IL1B is essential for the migration of immune cells to OECs. Specifically, IL1B regulates PMN migration and adhesion to bovine OECs, and PMNs accelerate inflammatory cytokine production from bovine OECs via a direct interaction. These phenomena may contribute to chronic oviductal inflammation, resulting in subfertility.

Keyphrases

oxidative stress
liver injury
liver fibrosis
drug induced
staphylococcus aureus
cystic fibrosis
pseudomonas aeruginosa
biofilm formation