Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample.
Naiara G BediagaConnie Li Wai SuenMichael J HallerStephen E GitelmanCarmella Evans-MolinaPeter A GottliebMarkus HippichAnette-Gabriele ZieglerLernmark ÅkeLinda A DiMeglioDiane K WherrettPeter G ColmanLeonard C HarrisonJohn M WentworthPublished in: Diabetologia (2021)
Prediction models based on a single OGTT blood draw accurately predict disease progression from stage 1 or 2 to stage 3 type 1 diabetes. The operational simplicity of M120, its validity across different at-risk populations and the requirement for 120 min sampling to stage type 1 diabetes suggest M120 could be readily applied to decrease the cost and complexity of risk stratification.