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Synthesis of Functionalized Indoles via Palladium-Catalyzed Aerobic Cycloisomerization of o-Allylanilines Using Organic Redox Cocatalyst.

Xiao-Shan NingMei-Mei WangJian-Ping QuYan-Biao Kang
Published in: The Journal of organic chemistry (2018)
A scalable and practical synthesis of functionalized indoles via Pd- tBuONO cocatalyzed aerobic cycloisomerization of o-allylanilines is reported. Using molecular oxygen as a terminal oxidant, a series of substituted indoles were prepared in moderate to good yields. The avoidance of hazardous oxidants, heavy-metal cocatalysts, and high boiling point solvents such as DMF and DMSO enables this method to be applied in pharmaceutical synthesis. A practical gram-scale synthesis of indomethacin demonstrates its application potential.
Keyphrases
  • heavy metals
  • high intensity
  • quantum dots
  • risk assessment
  • molecular docking
  • ionic liquid
  • molecularly imprinted
  • health risk
  • water soluble
  • drinking water
  • sewage sludge