Lipopolysaccharide exacerbates depressive-like behaviors in obese rats through complement C1q-mediated synaptic elimination by microglia.

Titikorn ChunchaiThirathada ChinchapoJirapas SripetchwandeeChanisa ThonusinSiriporn C ChattipakornSiriporn C Chattipakorn

Published in: Acta physiologica (Oxford, England) (2024)

Our findings suggest that LPS aggravates metabolic disturbances, neuroinflammation, microglial synaptic engulfment, and depressive-like behaviors in obese rats.

Keyphrases

inflammatory response
lps induced
lipopolysaccharide induced
adipose tissue
weight loss
metabolic syndrome
bipolar disorder
toll like receptor
type diabetes
neuropathic pain
stress induced
obese patients
traumatic brain injury
cognitive impairment
immune response
blood brain barrier