Amentoflavone regulates the miR-124-3p/CAPN2 axis to promote mitochondrial autophagy in HCC cells.

Fengting Zhu Jingwen Jiang Xuewu Chen Lei Fu Hui Liu Hui Zhang

Published in: Toxicology research (2024)

This study confirmed that AF regulated miR-124-3p/CAPN2 axis to restraint β-catenin nuclear translocation and then inhibit the wnt/β-catenin pathway, thereby promoting mitochondrial autophagy in HCC.

Keyphrases

oxidative stress
induced apoptosis
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation
cell cycle arrest
stem cells
epithelial mesenchymal transition
atrial fibrillation
transcription factor