TRAF3 Modulation: Novel Mechanism for the Anti-inflammatory Effects of the Vitamin D Receptor Agonist Paricalcitol in Renal Disease.

Sandra Rayego-MateosJose Luis Morgado-PascualJosé Manuel ValdivielsoAna Belén SanzEnrique Bosch-PanaderoRaúl R Rodrigues-DíezJesús EgidoAlberto OrtizEmilio González-ParraMarta Ruiz-Ortega

Published in: Journal of the American Society of Nephrology : JASN (2020)

These data suggest the anti-inflammatory actions of paricalcitol depend on TRAF3 modulation and subsequent inhibition of the noncanonical NF-κB2 pathway, identifying a novel mechanism for VDRA's effects. Circulating TRAF3 levels could be a biomarker of renal damage associated with the inflammatory state.

Keyphrases

anti inflammatory
oxidative stress
signaling pathway
lps induced
big data
nuclear factor
machine learning
immune response
inflammatory response
artificial intelligence