P2X7 receptor inhibition ameliorates ubiquitin-proteasome system dysfunction associated with Alzheimer's disease.
Carolina BianchiBeatriz Alvarez-CastelaoÁlvaro Sebastián-SerranoCaterina Di LauroLucia Soria-TobarAnnette NickeTobias EngelMiguel Diaz-HernandezPublished in: Alzheimer's research & therapy (2023)
Our work demonstrates the sustained and aberrant activation of P2X7R caused by Tau-induced neuroinflammation contributes to the UPS dysfunction and subsequent neuronal death associated with AD, especially in the hippocampus.