Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy.
Istvan BodiEllen Merete HagenGordon Thorpe IngleMichael P LunnPublished in: Clinical case reports (2020)
A 46-year-old male had 11-year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α-synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.