Sex- and time-specific associations of obesity with glycaemic traits: A two-step multivariate Mendelian randomization study.

Ye TianGuochen MaJing ZiYifan HuYaxian ZengHaoqi LiHang LuoShufang ShanJingyuan XiongGuo Cheng

Published in: Diabetes, obesity & metabolism (2024)

Our findings provide evidence for causal and independent effects of sex- and time-specific anthropometric traits on glycaemic variables, and highlight the importance of considering multiple obesity exposures at different time points in the life course.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
genome wide
weight gain
air pollution
adipose tissue
data analysis
physical activity