Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human.
Ying ZhouJinsong CaiWenhua ZhangXiaoxian GongShenqiang YanKemeng ZhangZhongyu LuoJianzhong SunQuan JiangMin LouPublished in: Annals of neurology (2020)
We revealed that both the glymphatic pathway and pMLVs might be impaired in the aging human brain through the novel, clinically available method to simultaneously visualize their clearance. Our findings also support that in humans, pMLVs are the downstream of the glymphatic pathway. Ann Neurol 2020;87:357-369.