Five New Phenylpropanoyl Phloroglucinol Derivatives from Leptospermum scoparium.
Ji-Hong GuJun-Shan LiuJia-Hui LinFen LiuZhen-Long WuYuan-Ru ZhengWen-Cai YeLei WangPublished in: Chemistry & biodiversity (2023)
Leptosperols C-G (1-5), five new phenylpropanoyl phloroglucinol derivatives were isolated from the leaves of Leptospermum scoparium. Compounds 1-3 are phenylpropanoyl phloroglucinol-sesquiterpene adducts with new carbon skeletons. Their structures with absolute configurations were elucidated by detailed spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculation. Compounds 2 and 3 exhibited moderate anti-inflammatory activity in zebrafish acute inflammatory models.
Keyphrases
- high resolution
- liver failure
- molecular docking
- structure activity relationship
- respiratory failure
- oxidative stress
- electron microscopy
- high intensity
- drug induced
- magnetic resonance imaging
- mass spectrometry
- dual energy
- hepatitis b virus
- computed tomography
- acute respiratory distress syndrome
- monte carlo
- mechanical ventilation