Reconfigurable Carbon Nanotube Multiplexed Sensing Devices.
Xinzhao XuPierrick ClémentJohnas Eklöf-ÖsterbergNancy Kelley-LoughnaneKasper Moth-PoulsenJorge L ChávezMatteo PalmaPublished in: Nano letters (2018)
Here we report on the fabrication of reconfigurable and solution processable nanoscale biosensors with multisensing capability, based on single-walled carbon nanotubes (SWCNTs). Distinct DNA-wrapped (hence water-soluble) CNTs were immobilized from solution onto different prepatterned electrodes on the same chip, via a low-cost dielectrophoresis (DEP) methodology. The CNTs were functionalized with specific, and different, aptamer sequences that were employed as selective recognition elements for biomarkers indicative of stress and neuro-trauma conditions. Multiplexed detection of three different biomarkers was successfully performed, and real-time detection was achieved in serum down to physiologically relevant concentrations of 50 nM, 10 nM, and 500 pM for cortisol, dehydroepiandrosterone-sulfate (DHEAS), and neuropeptide Y (NPY), respectively. Additionally, the fabricated nanoscale devices were shown to be reconfigurable and reusable via a simple cleaning procedure. The general applicability of the strategy presented, and the facile device fabrication from aqueous solution, hold great potential for the development of the next generation of low power consumption portable diagnostic assays for the simultaneous monitoring of different health parameters.
Keyphrases
- low cost
- water soluble
- carbon nanotubes
- label free
- walled carbon nanotubes
- loop mediated isothermal amplification
- high throughput
- photodynamic therapy
- single cell
- healthcare
- quantum dots
- public health
- atomic force microscopy
- real time pcr
- reduced graphene oxide
- sensitive detection
- mental health
- particulate matter
- solid state
- human health
- cell free
- circulating tumor cells
- risk assessment
- ionic liquid
- minimally invasive
- mass spectrometry
- heavy metals
- social media
- electron microscopy