Login / Signup

Effect of glecaprevir/pibrentasvir on weight-adjusted tacrolimus trough/dose ratios in heart and kidney transplant recipients.

Daryl U NnaniAlesa Y CoursonMaria AjaimyOmar SaeedSnehal R PatelSana AhmedJay A GrahamUlrich P Jorde
Published in: Transplant infectious disease : an official journal of the Transplantation Society (2021)
Initiation of G/P in heart or kidney transplant recipients induces a reversible change in tacrolimus metabolism. A 33%-50% tacrolimus dose reduction may be considered at the time of G/P initiation. Regardless of tacrolimus dose adjustment, tacrolimus trough levels should be monitored 3 days after initiation of G/P. No clear relationship between HCV viremic organ transplantation and rejection risk was found. Larger studies are warranted to validate these findings.
Keyphrases
  • heart failure
  • hepatitis c virus
  • body mass index
  • human immunodeficiency virus
  • weight gain