Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway.
Zijie YeDanyang ChenRuilin ZhengHaiyang ChenTiantian XuChangbing WangShibo ZhuXiaofeng GaoJin ZhangDian LiYueyin PangBing ZhuYinghua LiWei JiaPublished in: Journal of food biochemistry (2021)
Neuroblastoma (NB) is a solid tumor in the nervous system and has a high mortality rate in children. Curcumin has well-characterized anticancer properties, while there is no effective method in clinical treatment. MTT assays revealed that curcumin dramatically inhibited the proliferation of SK-N-SH cells. Compared with the control group, curcumin markedly restrained the migration of SK-N-SH cells. Curcumin induced SK-N-SH cell apoptosis by G2/M cycle arrest and activated caspase-3 activity. Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways. This finding demonstrated the application of curcumin is an effective strategy for the therapeutics of NB.
Keyphrases
- induced apoptosis
- cell cycle arrest
- signaling pathway
- cell death
- endoplasmic reticulum stress
- pi k akt
- oxidative stress
- dna damage
- reactive oxygen species
- type diabetes
- cell cycle
- epithelial mesenchymal transition
- diabetic rats
- cell proliferation
- young adults
- small molecule
- cardiovascular disease
- drug induced
- coronary artery disease
- combination therapy