Cell-Free Tumor DNA Dominant Clone Allele Frequency Is Associated With Poor Outcomes in Advanced Biliary Cancers Treated With Platinum-Based Chemotherapy.
Pedro Luiz Serrano Uson JuniorUmair MajeedJun YinGehan BotrusMohamad Bassam B SonbolDaniel H AhnJason S StarrJeremy C JonesHani M BabikerSamantha R InabinettNatasha WylieAshton W R BoyleTanios S Bekaii-SaabGregory J GoresRory SmootMichael BarrettBolni Marius NagaloNathalie MeuriceNatalie M ElliottJoachim PetitYumei ZhouMansi AroraChelsae DumbauldOumar BarroAlexander T BakerJames BogenbergerKenneth H BuetowAaron S MansfieldKabir ModyMitesh J BoradPublished in: JCO precision oncology (2022)
DCAF at diagnosis of advanced BTC can stratify patients who have worse outcomes when treated with upfront platinum-based chemotherapy. Each increase in %ctDNA decreases survival probabilities.