Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

Christine AltmannVerica VasicStefanie HardtJuliana HeidlerAnnett HäusslerIlka WittigMirko H H SchmidtIrmgard Tegeder

Published in: Molecular neurodegeneration (2016)

We infer that progranulin activates Notch signaling pathways, enhancing thereby the regenerative capacity of partially injured neurons, which leads to improved motor function recovery.

Keyphrases

peripheral nerve
stem cells
signaling pathway
mesenchymal stem cells
cell therapy
spinal cord
cell proliferation
tissue engineering
epithelial mesenchymal transition
induced apoptosis
oxidative stress
spinal cord injury