Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy.

Valentina GaribottoMichael WissmeyerZoi GiavriRachel GoldsteinYann SeimbilleMargitta SeeckOsman RatibSven HallerFabienne Picard

Published in: European journal of nuclear medicine and molecular imaging (2018)

We observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.

Keyphrases

genome wide
copy number
electronic health record
machine learning
binding protein
deep learning