Differential Associations of GAD Antibodies (GADA) and C-Peptide With Insulin Initiation, Glycemic Responses, and Severe Hypoglycemia in Patients Diagnosed With Type 2 Diabetes.

Baoqi FanCadmon K P LimEmily W M PoonEric S H LauHongjiang WuAimin YangMai ShiClaudia Ha-Ting TamSamuel Y S WongEric Kam-Pui LeeMaggie H T WangNatural H S ChuRisa OzakiAlice Pik-Shan KongElaine ChowRonald Ching-Wan Ma Andrea On Yan Luk Juliana Chung Ngor Chan

Published in: Diabetes care (2023)

There is considerable heterogeneity in autoimmunity and β-cell dysfunction in T2D with GADA+ and high CP associated with early insulin initiation, while GADA+ and low CP, increased the risk of severe hypoglycemia. Extended phenotyping is warranted to increase the precision of classification and treatment in T2D.

Keyphrases

type diabetes
glycemic control
end stage renal disease
single cell
ejection fraction
early onset
newly diagnosed
chronic kidney disease
machine learning
prognostic factors
peritoneal dialysis
high throughput
oxidative stress
cell therapy
drug induced
adipose tissue
replacement therapy
patient reported