Inflammation and central adiposity as mediators of depression and uncontrolled diabetes in the study on global AGEing and adult health (SAGE).
Allison C DonaAlicia M DeLouizeGeeta N EickElizabeth ThieleAarón Salinas RodríguezBetty Soledad Manrique EspinozaRicardo RobledoSalvador VillalpandoNirmala NaidooSomnath ChatterjiPaul KowalJ Josh SnodgrassPublished in: American journal of human biology : the official journal of the Human Biology Council (2020)
These findings suggest that central adiposity may be a more significant mediator between diabetes and depression than inflammation and account for the relationship between these disorders and inflammation. Depression may cause an increase in central adiposity, which then may lead to diabetes, but the increase in known systemic inflammatory pathways caused by central adiposity may not be the key pathological mechanism.