Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques.

Andreas EdsfeldtMaarten SwartPratibha SinghLea DibJiangming SunJennifer E ColeInhye ParkDania Al-SharifyAna PerssonMihaela NitulescuPatricia Das Neves Borges Christina KassiteridiMichael E GoddardRegent LeePetr VolkovMarju Orho-Melander Lars Maegdefessel Jan NillsonIrina UdalovaIsabel Goncalves Claudia Monaco

Published in: European heart journal (2022)

We demonstrate a mechanistic link between the IRF5, plaque macrophages, and plaque vulnerability to rupture. Interferon regulatory factor-5 is a potential candidate therapeutic target in human atherosclerosis.

Keyphrases

dendritic cells
coronary artery disease
endothelial cells
transcription factor
climate change
cardiovascular disease
induced pluripotent stem cells
type diabetes
human health