iPSC-derived Airway Epithelial Cells: Progress, Promise, and Challenges.
Fenggang YuFei LiuXiaohua LiangLinwei DuanQiongqiong LiGe PanChengyao MaMinmin LiuMingyue LiPeng WangXuening ZhaoPublished in: Stem cells (Dayton, Ohio) (2022)
Induced pluripotent stem cells (iPSCs) generated from somatic cell sources are pluripotent and capable of indefinite expansion in vitro. They provide an unlimited source of cells that can be differentiated into lung progenitor cells for the potential clinical use in pulmonary regenerative medicine. This review gives a comprehensive overview on recent progress toward the use of iPSCs to generate proximal and distal airway epithelial cells and mix lung organoids. Further, their potential applications and future challenges for the field are discussed, with a focus on the technological hurdles that must be cleared before stem cell therapeutics could be used for clinical treatment.
Keyphrases
- induced pluripotent stem cells
- stem cells
- induced apoptosis
- pulmonary hypertension
- single cell
- small molecule
- cell therapy
- cell cycle arrest
- human health
- risk assessment
- dna methylation
- drinking water
- big data
- cell proliferation
- climate change
- machine learning
- mesenchymal stem cells
- endoplasmic reticulum stress
- pi k akt