Human-Derived Induced GABAergic Progenitor Cells Improve Cognitive Function in Mice and Inhibit Astrocyte Activation with Anti-Inflammatory Exosomes.

Chunxia ChenZhaohui LanXihe TangWan ChenXing ZhouHua SuRixiang SuZhaolin ChenHongbo ChenYing GuoWenbing Deng

Published in: Annals of neurology (2024)

Taken together, these findings support the hypothesis that hiMGEs transplantation is an alternative treatment for neuronal loss in AD and demonstrate that exosomes with anti-inflammatory activity derived from hiMGEs are important factors for graft survival. ANN NEUROL 2024;96:488-507.

Keyphrases

mesenchymal stem cells
anti inflammatory
endothelial cells
stem cells
high glucose
diabetic rats
induced pluripotent stem cells
type diabetes
high fat diet induced
cell therapy
bone marrow
combination therapy
skeletal muscle