The role of HLA genetic variants in COVID-19 susceptibility, severity, and mortality: A global review.

Taraneh HoseinnezhadNasrin SoltaniSarina ZiaratiAbdolvahab MoradiMohammad Javad Mousavi

Published in: Journal of clinical laboratory analysis (2024)

Considering host genetic variations, particularly HLA genetic variants, is crucial for understanding COVID-19 susceptibility and severity. These findings have implications for personalized treatment and interventions based on an individual's genetic profile. However, further research is needed to unravel the precise mechanisms underlying the observed associations and explore the potential for targeted therapies or preventive measures based on HLA genetic variants.

Keyphrases

coronavirus disease
sars cov
genome wide
copy number
physical activity
cardiovascular events
respiratory syndrome coronavirus
cardiovascular disease
gene expression
coronary artery disease
human health
combination therapy