Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans.

Nima GharahdaghiSupreeth RudrappaMatthew S BrookWesam FarrashIskandar IdrisMuhammad Hariz Abdul AzizFawzi KadiKonstantinos PapaioannouBethan E PhillipsTanvir SianPhilip J HerrodDaniel J WilkinsonNathaniel J SzewczykKenneth SmithPhilip J Atherton

Published in: Journal of cachexia, sarcopenia and muscle (2022)

We conclude that endogenous T sufficiency has a central role in the up-regulation of molecular transducers of RET-induced muscle hypertrophy in humans that cannot be overcome by muscle mechano-transduction alone.

Keyphrases

skeletal muscle
high glucose
drug induced
endothelial cells
smoking cessation