Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases.

Published in: bioRxiv : the preprint server for biology (2023)

Mature autophagosomes in the axon are transported by the microtubule motor dynein, activated by JNK-interacting proteins 3 and 4 (JIP3/4). This motility is regulated by the small GTPases ARF6 and RAB10. The tight regulation of autolysosomal transport is essential for intracellular recycling to maintain neuronal homeostasis.

Keyphrases

spinal cord injury
blood brain barrier
optic nerve
signaling pathway
cell death
biofilm formation
induced apoptosis
cerebral ischemia
reactive oxygen species
oxidative stress
staphylococcus aureus
brain injury
endoplasmic reticulum stress