Trans-ethnic polygenic risk scores for body mass index: An international hundred K+ cohorts consortium study.

Hui-Qi QuJohn J ConnollyPeter KraftJirong LongAlexandre PereiraChristopher FlatleyConstance TurmanBram PrinsFrank MentchPaulo A LotufoPer MagnusMeir J StampferRulla TamimiA Heather EliassenWei ZhengGun Peggy Stromstad KnudsenOyvind HelgelandAdam S ButterworthHakon H HakonarsonPatrick M Sleimannull null

Published in: Clinical and translational medicine (2023)

Here we show that for a truly polygenic trait such as BMI adjusting the summary statistics of a well powered European ancestry study using trans-ethnic LD reference results in a score that is predictive across a range of ancestries including East Asians and three-way admixed Brazilians.

Keyphrases

body mass index
weight gain
physical activity
genome wide
gene expression