Gut microbial diversity, inflammation, and oxidative stress are associated with tacrolimus dosing requirements early after heart transplantation.
Douglas L JenningsBruno BohnAmelia ZuverDuygu OnatMaureen GaineEugene RoyzmanJonathan HupfDanielle BrunjesFarhana LatifSusan RestainoArthur Reshad GaranVeli K TopkaraHiroo TakayamaKoji TakedaYoshifumi NakaMaryjane FarrRenu NandakumarAnne-Catrin UhlemannPaolo C ColomboRyan T DemmerMelana YuzefpolskayaPublished in: PloS one (2020)
Our pilot study observed gut microbial alpha diversity to be increased while inflammation and oxidative stress were reduced among patients requiring higher TAC doses early after HT.