Purine versus non-purine xanthine oxidase inhibitors against cyclophosphamide-induced cardiac and bone marrow toxicity in rats.

A A El-SheikhWalaa Yehia AbdelzaherA A GadSeham A Abdel-Gaber

Published in: Human & experimental toxicology (2019)

These results suggest that both XO inhibitors tested; ALL and FEB can ameliorate CYC-induced cardiotoxicity. However, only FEB can protect against CYC-induced myelotoxicity, whereas ALL, to the contrary, might aggravate it.

Keyphrases

high glucose
bone marrow
diabetic rats
oxidative stress
drug induced
metabolic syndrome
endothelial cells
uric acid