Pregnant women are left out of RCTs. To the greatest extent possible, future research should include pregnant persons in RCTs, including PK studies, strictly considering maternal and fetal safety. Alternative innovative approaches/models need to be developed to obtain reliable data about rational pharmacotherapy of ARVs in the effective PMTCT of HIV, with maximum safety.
Keyphrases
- pregnant women
- hiv infected
- pregnancy outcomes
- hiv positive
- human immunodeficiency virus
- hiv aids
- antiretroviral therapy
- hepatitis c virus
- hiv infected patients
- hiv testing
- birth weight
- big data
- south africa
- smoking cessation
- machine learning
- adverse drug
- data analysis
- deep learning
- weight loss
- body mass index
- case control