Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis-methylomics of cholestatic liver disease.
Brian D JuranBryan M McCauleyElizabeth J AtkinsonErik M SchlichtJackie K BianchiJason M VollenweiderHong YeNicholas F LaRussoGregory J GoresZhifu SunKonstantinos N LazaridisPublished in: Hepatology communications (2024)
This study provides insights into methylation profiles of patients that support current concepts of disease mechanisms and provide novel data to inspire future research. Studies to corroborate our findings and expand into other -omics layers will be invaluable to further our understanding of these rare diseases with the goal to improve and individualize prognosis and treatment.
Keyphrases
- end stage renal disease
- dna methylation
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- gene expression
- prognostic factors
- liver injury
- machine learning
- big data
- patient reported outcomes
- current status
- single cell
- combination therapy
- deep learning
- case control
- drug induced
- smoking cessation