Verinurad does not prolong QTc interval: a thorough QT study using concentration-QTc modelling.

Joanna ParkinsonCorina DotaChristian KällgrenChrister GottfridssonMagnus BjursellShira PerlThomas KӧrnickeDinko RekićSusanne Johansson

Published in: British journal of clinical pharmacology (2022)

As the effect on ΔΔQTcF was below the threshold for regulatory concern (10 msec) at the supratherapeutic exposure, it can be concluded that verinurad and allopurinol treatment does not induce QTcF prolongation at the highest clinically relevant exposures.

Keyphrases

drug induced
air pollution
transcription factor
combination therapy
replacement therapy