A new cyclohexenone derivative from phomopsis sp. XM-01.

A new cyclohexenone derivative, phomopine ( 1 ), together with five known compounds ( 2-6 ) were isolated from Phomopsis sp. XM-01. The structure of 1 was determined by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. In vitro bioassays, compounds 1 and 2 exhibited potent antimicrobial activities against Candida albicans and Staphylococcus aureus with their corresponding minimum inhibitory concentrations (MICs) of 64 μg/mL and 16 μg/mL, respectively.