Risk factors for the development of second primary esophageal squamous-cell carcinoma after endoscopic resection for esophageal squamous-cell carcinoma according to genetic polymorphisms related to alcohol and nicotine metabolism.
Chikatoshi KatadaTetsuji YokoyamaKanae MureHisashi DoyamaHiroyoshi NakanishiYuichi ShimizuKeiko YamamotoYasuaki FurueMasashi TamaokiTomoyuki KoikeYoshiro KawaharaHirofumi KiyokawaMaki KonnoAkira YokoyamaShinya OhashiHideki IshikawaAkira YokoyamaManabu MutoPublished in: Japanese journal of clinical oncology (2023)
Slow-metabolizing alcohol dehydrogenase 1B may be a significant risk factor for the development of second primary esophageal squamous-cell carcinoma. In addition, inactive aldehyde dehydrogenase 2 and poorly-metabolizing cytochrome P450 2A6 may be important factors.
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