Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Grace M HudsonKyle L FlanniganSarah L EricksonFernando A VicentiniAlexandra ZamponiChristina L HirotaLaurie AlstonChristophe AltierSubrata GhoshKevin P RiouxSridhar ManiThomas K ChangSimon A Hirota

Published in: British journal of pharmacology (2017)

Our results support the notion that xenobiotic sensing is altered during intestinal inflammation, and suggest that CAR activation may prove effective in enhancing mucosal healing in patients with IBD.

Keyphrases

ulcerative colitis
oxidative stress